Synthesis, antioxidant and anti-microbial properties of two organoselenium compounds

The aim of this study is synthesis of two different series of organoselenium compounds and available in vitro antioxidant and antimicrobial properties of these synthetic compounds. The synthetic compounds were identified by [1]HNMR [300 MHz], [13]C-NMR [75.5 MHz], FT-IR spectroscopic techniques and micro analysis. Antioxidant properties of two synthetic organoselenium compounds were determined by 1, 1- diphenyl-2-picrylhydrazyl [DPPH] radical method, reducing power assay and beta-carotene bleaching method as in vitro. Antimicrobial effects of samples were assessed by the agar dilution procedure and using gram positive and gram-negative bacteria and yeast strains. Although 1, 3-di-p-methoxybenzylpyrimidine- 2-selenone showed better antiradical activity in DPPH test and higher protective activity on beta- carotene, 1-isopropyl-3-methylbenzimidazole-2-selenone was found to be better in reducing power and antimicrobial activity

Propolis attenuates oxidative injury in brain and lung of nitric oxide synthase inhibited rats

The blocking of nitric oxide synthase [NOS] activity may reason vasoconstriction with formation of reactive oxygen species. Propolis has biological and pharmacological properties, such as antioxidant. The aim of this study was to examine the antioxidant effects of propolis which natural product on biochemical parameters in brain and lung tissues of acute nitric oxide synthase inhibited rats by Nco-nitro-L-arginine methyl ester [L-NAME]. Rats have been received L-NAME [40 mg/kg, intraperitoneally], NOS inhibitor for 15 days to produce hypertension and propolis [200mg/kg, by gavage] the lastest 5 of 15 days. There were the increase [P0<001] in the malondialdehyde levels in the L-NAME treatment groups when compared to control rats, but the decrease [P<001] in the catalase activities in both brain and lung tissues. There were statistically changes [P<001] in these parameters of L-NAME+propolis treated rats as compared with E-NAME-treated group. The application of L-NAME to the Wistar rats resulted in well developed oxidative stress. Also, propolis may influence endothelial NO production. Identification of such compounds and characterisation of their cellular actions may increase our knowledge of the regulation of endothelial NO production and could provide valuable clues for the prevention or treatment of hypertensive diseases and oxidative stress